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Tables
Table 1. List of polymorphisms that were reviewed and indication whether they were meta-analysed with reference of the identified studies
Table 2. List of genes and variants that were selected for meta-analysis (sorted by gene pathway).
Meta-analyses
Adhesion molecules pathway
Tables of meta-analyses for genes in the adhesion molecule pathway (CDH1, MMP1, MMP3, MMP9).
Forest plots for genes in the adhesion molecule pathway (CDH1, MMP1, MMP3, MMP9).
Alcohol metabolism pathway
Tables of meta-analyses for genes in the alcohol pathway (ADH1B, ADH1C, ALDH2).
Forest plots for genes in the alcohol pathway (ADH1B, ADH1C, ALDH2).
Angiogenesis pathway
Tables of meta-analyses for genes in the angiogenesis pathway (VEGF).
Forest plots for genes in the angiogenesis pathway (VEGF).
Base-excision repair pathway
Tables of meta-analyses for genes in the base-excision repair pathway (MGMT, MUTYH, OGG1, XRCC1, XRCC3).
Forest plots for genes in the base-excision repair pathway (MGMT, MUTYH, OGG1, XRCC1, XRCC3).
Inflammation/ immune response pathway
Tables of meta-analyses for genes in the inflammation/ immune response pathway (IL6, IL8, IL10, PPAR-gamma, PTGS2/COX2, TNF-alpha, NOD2).
Forest plots for genes in the inflammation/ immune response pathway (IL6, IL8, IL10, PPAR-gamma, PTGS2/COX2, TNF-alpha, NOD2).
Inhibition of cell growth pathway
Tables of meta-analyses for genes in the Inhibition of cell growth pathway (CCND1, TGFB1, TGFBR1).
Forest plots for genes in the Inhibition of cell growth pathway (CCND1, TGFB1, TGFBR1).
Insulin related pathway
Tables of meta-analyses for genes in the insulin related pathway (IGF1, IGFBP3).
Forest plots for genes in the Inhibition of cell growth pathway (IGF1, IGFBP3).
Iron metabolism pathway
Tables of meta-analyses for genes in the iron metabolism pathway (HFE).
Forest plots for genes in the iron metabolism pathway (HFE).
Lipid metabolism pathway
Tables of meta-analyses for genes in the lipid metabolism pathway (ApoE).
Forest plots for genes in the lipid metabolism pathway (ApoE).
Mitotic control pathway
Tables of meta-analyses for genes in the mitotic control pathway (STK15).
Forest plots for genes in the mitotic control pathway (STK15).
One carbon metabolism pathway
Tables of meta-analyses for genes in the one carbon metabolism pathway (MTHFR, MTR, MTRR, TS).
Forest plots for genes in the one carbon metabolism pathway (MTHFR, MTR, MTRR, TS).
Rare, high penetrance genes
Tables of meta-analyses for rare, high penetrance genes (APC, MLH1).
Forest plots for rare, high penetrance genes (APC, MLH1).
Substrate metabolism pathway
Tables of meta-analyses for genes in the substrate metabolism pathway (CYP1A1, CYP1A2, CYP1B1, CYP2C9, CYP2E1, GSTA1, GSTM1, GSTP1, GSTT1, NAT1, NAT2, NQ01).
Forest plots for genes in the substrate metabolism pathway (CYP1A1, CYP1A2, CYP1B1, CYP2C9, CYP2E1, GSTA1, GSTM1, GSTP1, GSTT1, NAT1, NAT2, NQ01).
Tumour supressor genes
Tables of meta-analyses for tumour supressor genes (TP53, MDM2).
Vitamin D and calcium metabolism pathway
Tables of meta-analyses for genes in the vitamin D and calcium metabolism pathway (VDR).
Forest plots for genes in the vitamin D and calcium metabolism pathway (VDR).
Common low penetrance variants that were identified from Genome Wide Association Studies
Tables of meta-analyses for Common low penetrance variants that were identified from Genome Wide Association Studies.
Forest plots for Common low penetrance variants that were identified from Genome Wide Association Studies.
Additional analyses
Summary crude odds ratios (ORs) and 95% Confidence Intervals (95% CI) in white populations for variants, which 95% Cls excluded unity in the main analysis
Bayesian False Discovery Probability (BFDP) values. (BFDP level of noteworthiness 0.2, with false discovery being three times more costly than false non discovery)
Summary crude odds ratios (ORs) and 95% Confidence Intervals (95% CI) based on the model free approach for those SNPs that were identified as true positives after applying the BFDP and Venice criteria
