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The University of Edinburgh

The University of Edinburgh | College of Medicine and Veterinary Medicine |
School of Molecular, Genetic and Population Health Sciences

Centre for Population Health Sciences

Strapline photo
Photo of Harry Campbell

Professor Harry Campbell

Professor of Genetic Epidemiology and Public Health

Tel: 0131 650 3218
Fax: (0131) 650 6909
Harry.Campbell@ed.ac.uk

Role

  • Co-Director of Centre for Population Health Sciences
  • Co-Director WHO Collaborating Centre for Population Health Research and Training
  • Programme lead for public health, Research Governance Committee, NHS Lothian

Teaching Responsibilities

Undergraduate
  • Co-ordinator social sciences and public health programme theme
Postgraduate
  • MPH: Course leader - Global Health Epidemiology
  • MPH: Course lecturer Genetic Epidemiology; Epidemiology for Public Health; Epidemiology of non communicable diseases
  • MSc programmes in Life Sciences (cancer biology): course lecturer

Research Interests

  1. Genetic epidemiology studies
    • Colorectal cancer genetics
    • Mapping of complex disease QTL in genetic isolate populations
  2. Epidemiology of glycans in health and disease
  3. International Health
  4. Health Services Research

Current Research Involvement

  1. Genetic epidemiology studies
    1. Genetic isolate populations
      We have established cohort studies recruiting families / extended pedigrees and measuring a wide range of quantitative traits of public health importance in the Dalmatian islands, Croatia and in Orkney island, Scotland. We have also established a research collaboration linking 5 genetic isolate populations throughout Europe (EUROSPAN).

      Research areas
      • QTL mapping on wide variety of disease-related traits
      • Population genetics characterisation of isolate populations
      • Inbreeding depression effects on late-onset traits
    2. Contribution to other collaborative genetic epidemiology studies
      • Scottish Family Health Study (Generation Scotland)
      • Member of many international GWAS consortia
  2. Colorectal cancer genetics (together with Prof Malcolm Dunlop and colorectal cancer genetics group at MRC Human Genetics Unit)
    We have recruited about 4,000 patients with colorectal cancer in Scotland, 1,400 of these with early onset (under 55 years of age). We have also recruited population and family based controls and environmental exposure /survival / clinical data (SOCCS study)

    Research areas include
    1. Epidemiology of mismatch repair gene mutations
      • Prevalence, penetrance, modifiers etc
    2. Identification of novel genetic variants
      • Candidate gene / association approach
      • Genome wide screen / association approach - Exome sequencing
      • Field synopses of colorectal adenoma / carcinoma genetics
  3. Glycomic epidemiology studies
    We have undertaken GWAS studies of plasma and IgG N-glycans and associated follow on studies in disease cohorts. - current funded projects include
    • IBD BIOM - inflammatory disease glycomics
    • MIMOmics -
    • High GLYCAN
  4. International Health
    I have long standing interests in several aspects of childhood respiratory infections in developing countries - epidemiology, prevention and treatment. - current funded projects include:

    • WHO / UNICEF Child Health Epidemiology Reference Group (now Maternal and Child health Estimation and Evaluation group
    • Improving Coverage Measurement in MNCH (ICM) Core Group
    • RSV Global Estimation Network
    • Optimal use of clinical signs for diagnosis and prognosis of childhood pneumonia

Other Responsibilities/Activities

  • Member of Research Grants Committee, Research Council of Norway
  • Co-editor Journal of Global Health

Further Information

Work History

Previous Appointments
1986-1989 Epidemiologist / Research Clinician, MRC, The Gambia, West Africa
1989-1992 Medical Officer, World Health Organisation, Geneva, Switzerland
1992-1995 Consultant in Public Health Medicine, Fife Health Board, Scotland
1995-2004 Senior Lecturer then Reader in Genetic Epidemiology / Public Health, University of Edinburgh

Selected grants

  • Systematic literature review in multiple language databases to identify studies reporting data (by gender) on hospitalisations and mortality for the three leading causes of child mortality (UNICEF, 2014-2014) Nair H, Campbell H, Rudan I
  • Maternal and Child Epidemiology (Johns Hopkins University, 2014-2016) Rudan I, Campbell H, Nair H
  • Optimal use of clinical signs for diagnosis and prognosis of childhood pneumonia (World Health Organization, 2014-2015) Nair H, Campbell H
  • Improving current global estimates of morbidity and mortality due to RSV - associated acute lower respiratory infections in young children through acquisition of novel data and disease burden modelling (Bill and Melinda Gates Foundation, 2013-2015) Nair H, Campbell H, Rudan I, McAllister DA
  • Cost of treatment of childhood pneumonia under the revised WHO guidelines and the cost projection for management in 2015 (World Health Organization, 2013-2013) Nair H, Campbell H, Zhang S
  • Improving coverage measurement for MNCH: linking household survey data to assessments of service provision (Johns Hopkins University, 2013-2013) Campbell H, Nair H, Brondi L
  • Systematic literature review of relative risks / odds ratio for pneumonia in children associated with HIV infection (World Health Organization, 2013-2013) Campbell H, Nair H
  • Estimating the annual number of deaths from multidrug-resistant TB in the world (WHO, 2013-2013) Nair H, Brondi L, Campbell H
  • WHO Manual on Influenza Burden of Disease (Global Influenza Program, World Health Organization, Geneva, 2011-2012) Nair H, Campbell H
  • Analysis of landscape and potential impact of diagnostics for neonatal sepsis. (Bill and Melinda Gates Foundation, 2010-2012) Rudan I., Campbell H.
  • A mendelian randomisation study of vitamin D on colorectal cancer risk (Chief Scientist Office, 2009-2011) Campbell H, Theodoratou E, Dunlop M, McKeigue P, Davey Smith G, Farrington SM
  • Identifying susceptibility loci for osteoporosis by genome wide scan in the UK population isolate of Orkney. (Arthritis Research Council, 2007-2010) Ralston S, Wilson J, Wright A ,Campbell H, Albagha O, Wild S
  • EUROpean Special Populations reseArch Network (EUROSPAN): quantifying and harnessing genetic variation for gene discovery. : MRC Human Genetics Unit, Erasmus University (N), Zagreb University (Cr), National Research Center for Environment and Health Munich (G), Uppsala University (Sw), European Research Academy (It), IntegraGen (Fr). (European Union (FP6), 2006-2009) Campbell H et al
  • The Genetic Analysis of Ocular Morphometric Traits Related to Primary Open Angle Glaucoma Susceptibility in the Population Isolate of Orkney (The Glaucoma Inheritance Study of Orkney, GISO). (Chief Scientist Office, Scottish Executive, 2006-2008) Karunaratne V, Wright A, Wilson J, Fleck B, Campbell H
  • The Role of Base Excision Repair defects in predisposition to colorectal cancer. (Chief Scientist Office, Scottish Executive, 2006-2008) Melton D, Campbell H et al
  • Mapping genes underlying complex quantitative traits in isolate populations - Phase III. (Medical Research Council UK, 2005-2008) Rudan I, Wright A, Campbell H, Carothers A
  • Scottish Family Heart Study (Genetics and Healthcare Initiative). (Scottish Executive, 2005-2008) Morris A, Campbell H et al (CI University of Dundee)
  • Genome Scan To Identify Common Low Penetrance Alleles Contributing to Colorectal Cancer Aetiology. (CRUK, 2005-2007) Dunlop M, Campbell H
  • Statistical methods for describing gene-environment interactions in cardiovascular disease risk factors (Health Services Research studentship). (Chief Scientist Office, 2005-2008) Anderson N, Wild S, Campbell H
  • Investigating the effects of inbreeding on human quantitative traits. (National Institutes of Health, 2004-2006) Rudan I, Campbell H et al
  • Genetic dissection of high myopia using threshold-defined case and control subjects from a Scottish isolate sub-population, the Western Isles. (Chief Scientist Office, Scottish Executive, 2004-2007) Vitart V, Wright A, Campbell H et al (CI MRC Human Genetics)
  • The importance of cell cycle control and DNA repair gene polymorphisms in genetic predisposition to melanoma. (Chief Scientist Office, 2004-2007) Melton D W, Anderson N, Campbell H, Doherty V, Kavanagh G, Rees J
  • Genetic analysis of cardiovascular disease-related traits in Orkney. (Chief Scientist Office, 2004-2007) Wilson J, Campbell H, Wright A, Wild S, Visscher P, Carothers A et al
  • Genetics of Complex Traits and Diseases in Croatian genetic isolate. (The Royal Society, 2003-2005) Rudan I, Campbell H
  • An investigation of genetic determinants of susceptibility and disease behaviour in early inflammatory bowel disease. (Wellcome Trust Programme Grant, 2003-2008) Satsangi J, Campbell H et al
  • National Translational Cancer Research Network. (Department of Health, 2003-2008) Dunlop M, Campbell H et al
  • Utilising genetics to combat colorectal cancer. (Cancer Research UK Programme Grant, 2003-2008) Dunlop M, Campbell H
  • Associations of mutations in the human homolog of the MutY gene with early onset colorectal cancer. (Chief Scientist Office, Scottish Executive, 2003-2006) Farrington S, Dunlop M, Campbell H et al
  • Mapping genes underlying complex quantitative traits in Croatian isolate population - Phase I. (Medical Research Council, 2002-2002) Wright A, Hayward C, Hastie N, Rudan I, Campbell H et al (CI MRC Human Genetics)
  • Mapping genes underlying complex quantitative traits in Croatian isolate population - Phase II. (Medical Research Council, 2002-2005) Wright A, Hayward C, Hastie N, Rudan I, Campbell H (CI MRC Human Genetics)
  • Centre for colorectal cancer research. (Digestive Disorders Foundation, 2002-2007) Campbell H, Dunlop M, Satsangi J, Jodrell D

Selected publications

Link to Edinburgh Research Explorer for up-to-date publications list

Selected publications

  • Bolton JL, Hayward C, Direk N, Lewis JG, Hammond GL, Hill LA, et al (inc Wilson JF, Campbell H, Rudan I, Wild SH, Price JF). Genome Wide Association Identifies Common Variants at the SERPINA6/SERPINA1 Locus Influencing Plasma Cortisol and Corticosteroid Binding Globulin. PLoS Genet 2014;10(7):e1004474 DOI Link
  • Vimaleswaran KS, Cavadino A, Berry DJ, Jorde R, Dieffenbach AK, Lu C, et al (inc Zgaga L, Fraser RM, McLachlan S, Theodoratou E, Wilson JF, Rudan I, Campbell H, Price JF). Association of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study. Lancet Diabetes Endocrinol 2014; published online 25 June DOI Link
  • Theodoratou A, Campbell H, Ventham N T, Kolarich D, Pučić-Baković M, Zoldoš V, Fernandes D, Pemberton I K, Rudan I, Kennedy N A, Wuhrer M, Nimmo E, Annesse Vito, McGovern D P B, Satsangi J, Lauc G DOI Link
  • Genetic Investigation of Anthropometric Traits (GIANT) Consortium (inc J Bolton, H Campbell, G Fowkes, RM Fraser, J Price, I Rudan, SH Wild, JF Wilson). Quality control and conduct of genome-wide association meta-analyses. Nature Protocols 2014;9(5):1192-212 DOI Link
  • DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium (inc H Campbell, RM Fraser, JF Price, I Rudan, JF Wilson). Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nature Genetics 2014; 46(3):234-244 DOI Link
  • Adeloye D, Chan KY, Rudan I, Campbell H. An estimate of asthma prevalence in Africa: a systematic analysis. Croat Med J. 2013 December; 54(6): 519–531 DOI Link
  • Do R, Willer CJ, Schmidt EM, Sengupta S, Gao C, Peloso GM, et al (inc Fraser RM, Bolton JL, Rudan I, Wild SH, Wilson JF, Campbell H, Price JF). Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet 2013; published online 6 October DOI Link
  • Global Lipids Genetics Consortium (inc RM Fraser, JL Bolton, I Rudan, SH Wild, JF Wilson, H Campbell, JF Price). Discovery and refinement of loci associated with lipid levels. Nat Genet 2013; published online 6 October DOI Link
  • Lamberti LM, Zakaria-Grkovic I, Walker CLF, Theodoratou E, Nair H, Campbell H, Black RE.Breastfeeding for reducing the risk of pneumonia morbidity and mortality in children under two: a systematic literature review and meta-analysis. BMC Public Health 2013, 13(Suppl 3):S18 DOI Link
  • Nair H, Lau ESM, Brooks WA, Seong AC, Theodoratou E, Zgaga L, Huda T, Jadhav SS, Rudan I, Campbell H. An evaluation of the emerging vaccines against influenza in children. BMC Public Health 2013, 13(Suppl 3):S14 DOI Link
  • Rudan I, O'Brien KL, Nair H, Liu L, Theodoratou E, Qazi S, Lukšić I, Fischer Walker CL, Black RE, Campbell H; Child Health Epidemiology Reference Group (CHERG). Epidemiology and etiology of childhood pneumonia in 2010: estimates of incidence, severe morbidity, mortality, underlying risk factors and causative pathogens for 192 countries. J Glob Health 2013; 3(1):10401 DOI Link
  • Rudan I, Nair H, Marušić A, Campbell H. Reducing mortality from childhood pneumonia and diarrhoea: The leading priority is also the greatest opportunity. J Glob Health 2013; 3(1:10101 DOI Link
  • Jackson S, Mathews KH, Pulanic D, Falconer R, Rudan I, Campbell H, Nair H. Risk factors for severe acute lower respiratory infections in children: a systematic review and meta-analysis. Croat Med J. 2013;54(2):110-21 DOI Link
  • Luksic I, Kearns PK, Scott F, Rudan I, Campbell H, Nair H. Viral etiology of hospitalized acute lower respiratory infections in children under 5 years of age - a systematic review and meta-analysis. Croat Med J. 2013;54(2):122-34. DOI Link
  • Luksic I, Clay S, Falconer R, Pulanic D, Rudan I, Campbell H, Nair H. Effectiveness of seasonal influenza vaccines in children - a systematic review and meta-analysis. Croat Med J. 2013;54(2):135-45 DOI Link
  • Walker CL, Rudan I, Liu L, Nair H, Theodoratou E, Bhutta ZA, O'Brien KL, Campbell H, Black RE. Global burden of childhood pneumonia and diarrhoea. Lancet 2013; 381(9875):1405-16 DOI Link
  • Nair H, Simões EA, Rudan I, Gessner BD, Azziz-Baumgartner E, Zhang JS, Feikin DR, Mackenzie GA, Moïsi JC, Roca A, Baggett HC, Zaman SM, Singleton RJ, Lucero MG, Chandran A, Gentile A, Cohen C, Krishnan A, Bhutta ZA, Arguedas A, Clara AW, Andrade AL, Ope M, Ruvinsky RO, Hortal M, McCracken JP, Madhi SA, Bruce N, Qazi SA, Morris SS, El Arifeen S, Weber MW, Scott JA, Brooks WA, Breiman RF, Campbell H. Global and regional burden of hospital admissions for severe acute lower respiratory infections in young children in 2010: a systematic analysis. Lancet 2013; 381(9875):1380-90 DOI Link
  • Rudan I, Theodoratou E, Zgaga L, Nair H, Chan KY et al. Setting priorities for development of emerging interventions against childhood pneumonia, meningitis and influenza. Journal of Global Health 2012; 2(1) : 33-39
  • The Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC) (inc RM Fraser, JL Bolton, GR Fowkes, SH Wild, I Rudan, H Campbell, JF Wilson, JF Price). Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nature Genetics 2012; published online 12 August DOI Link
  • The DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium (inc RM Fraser, H Campbell, JF Price, JF Wilson). Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nature Genetics 2012; published online 12 August DOI Link
  • Theodoratou E, Zhang JS, Kolcic I, Davis AM, Bhopal S, Nair H, et al. Estimating pneumonia deaths of post-neonatal children in countries of low or no death certification in 2008. PLoS One. 2011; 6(9): e25095.
  • Waters D, Jawad I, Ahmad A, Luksic I, Nair H, et al. Aetiology of community-acquired neonatal sepsis in low and middle income countries. Journal of Global Health. 2011; 1(2) : 152-168
  • Rudan I, Theodoratou E, Nair H, Marusic A, Campbell H, et al. Reducing the burden of maternal and neonatal infections in low income settings. Journal of Global Health. 2011; 1(2) : 106-109
  • Rudan I, Chopra M, Aulchenko Y, Baqui A, Bhutta Z, Edmond K, Horta B, Klugman K, Lanata C, Madhi S, Nair H, et al. The case for launch of an international DNA-based birth cohort study. Journal of Global Health. 2011; 1(1) : 39-45
  • Nair H, Brooks WA, Katz M, Roca A, Berkley JA, Madhi SA et al. Global burden of respiratory infections due to seasonal influenza in young children: a systematic review and meta-analysis. Lancet. 2011; 378(9807): 1917-30
  • Rudan I, El Arifeen S, Bhutta ZA, Black RE, Brooks A, Chan KY, Chopra M, Duke T, Marsh D, Pio A, Simoes EA, Tamburlini G, Theodoratou E, Weber MW, Whitney CG, Campbell H, Qazi SA; WHO/CHNRI Expert Group on Childhood Pneumonia. Setting research priorities to reduce global mortality from childhood pneumonia by 2015. PLoS Med 2011; 8:e1001099. DOI Link
  • Rudan I, Chan KY, Zhang JSF, Theodoratou E, Feng XL, Salomon J, Lawn JE, Cousens S, Black RE, Guo Y, Campbell H on behalf of WHO/UNICEF’s Child Health Epidemiology Reference Group (CHERG). Causes of deaths in children younger than five years in China in 2008. The Lancet. 2010; 375:1083–89
  • Nair H, Gessner BD, Nokes DJ, Theodoratou E, Rudan I, Madhi SA, Simoes EAF, Campbell H. Childhood mortality due to respiratory syncytial virus. AUTHORS' REPLY. Lancet. 2010;376(9744): 872-73.
  • Nair H, Nokes DJ, Gessner BD, Dherani M, Madhi SA, Singleton RJ, et al. Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis. Lancet. 2010; 375(9725):1545-55.
  • Dupuis J et al. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet 2009: in press.
  • Campbell H, Rudan I, Bittles AH, Wright AF. Human population structure, genome autozygosity and human health. Genome Med. 2009; 1: 91.
  • Rudan I, Campbell H. The deadly toll of Streptococcus pneumoniae and Haemophilus Influenzae type B disease. Lancet 2009: 374: 854-6.
  • Navarro P, Vitart V, Hayward C, Zgaga L, Juricic D, Tenesa A, Polasek O, Hastie ND, Rudan I, Campbell H, Haley CS, Wright AF, Knott A. Genetic comparison of Croatian isolate and CEPH European Founders. Genetic Epidemiol 2009: in press.
  • Hicks AA, Pramstaller PP, Johansson A, Vitart V, Rudan I, Ugocsai P, Aulchenko Y, Franklin CS, Liebisch G, Jonasson I, Pattaro C, Hayward C, Isaacs A, Huffman J, Gnewuch C, Marroni F, Polasek O, Demirkan A, Kolcic I, Schweinbacher C, Igl W, Biloglav Z, Witteman JCM, Pichler I, Zaboli G, Hastie N, Oostra BA, Wild SH, Meitinger T, Gyllensten U, van Duijn CM, Wilson JF, Wright AF, Schmitz G, Campbell H. Genetic determinants of circulating sphingolipid concentrations PLoSGenetics 2009: in press
  • Khoury MJ, Bernstein J, Bertram L, Boffetta P, Burton P, Butterworth A, Campbell H, Chanock S, Chockalingam A, Dolan S, Fortier I, Furberg H, Garcia-Closas M, Gwinn M, Higgins J, Janssens C, Manolio T, Morton C, Ostell J, Owen R, Pagon R, Rebbeck T, Rothman N, Seminara D, Vineis P, Winn D, Yu W, Ioannidis JPA. Genome Wide Association Studies, Field Synopses and the Development of an Encyclopedic Knowledge Base on Genetic Variation and Human Diseases Amer J Epidemiol 2009: in press.
  • Grant G, Campbell H, Dowell S, English M, Graham S, Klugman K, Mulholland K, Steinhoff M, Weber M, Qazi S. Review and Recommendations for Treatment of Childhood Pneumonia. Lancet Infect Dis 2009: 9: 185 - 96.
  • Subhi R, Adamson M, Campbell H, Weber M, Smith K, Ashraf H, Berkley J, Bose A, Brent A, Brooks WA, Bruce N, Chisti MJ, Gessner BD, Gyr N, Mwaniki M, Nadjm B, Nokes DJ, Okiro EA, Reyburn H, Sutanto A, Zaman A, Duke T. The burden of hypoxaemia among children in developing countries. Lancet Infect Dis 2009: 9: 219-27
  • Pattaro C, Aulchenko YS, Isaacs A, Vitart V, Hayward C, Franklin CS, Polasek O, Kolcic I, Biloglav Z, Campbell S, Hastie N, Lauc G, Meitinger T, Oostra BA, Gyllensten U, Wilson JF, Pichler I, Hicks AA, Campbell H, Wright AF, Rudan I, van Duijn CM, Riegler P, Marroni F, Pramstaller PP. Genome-wide linkage analysis of serum creatinine in three isolated European populations. Kidney Int. 2009 Apr 22. [Epub ahead of print]
  • Mascalzoni D, Janssens ACJW, Stewart A, Pramstaller P, Gyllensten U, Rudan I, van Duijn CM, Wilson JF, Campbell H, McQuillan R. Comparison of patient information and informed consent forms of five European family-based studies in genetic isolated populations Eur J Human Genet 2009: in press
  • Lauc G, Rudan I, Campbell H, Rudd PM. Complex genetics of protein glycosylation. Rev Molec Biosystems 2009: in press [review article]
  • Aulchenko YS, Ripatti S, Lindqvist I, Boomsma D, Heid IM, Pramstaller PP, Penninx BW, Janssens AC, Wilson JF, Spector T, Martin NG, Pedersen NL, Kyvik KO, Kaprio J, Hofman A, Freimer NB, Jarvelin MR, Gyllensten U, Campbell H, Rudan I, Johansson A, Marroni F, Hayward C, Vitart V, Jonasson I, Pattaro C, Wright A, Hastie N, Pichler I, Hicks AA, Falchi M, Willemsen G, Hottenga JJ, de Geus EJ, Montgomery GW, Whitfield J, Magnusson P, Saharinen J, Perola M, Silander K, Isaacs A, Sijbrands EJ, Uitterlinden AG, Witteman JC, Oostra BA, Elliott P, Ruokonen A, Sabatti C, Gieger C, Meitinger T, Kronenberg F, Döring A, Wichmann HE, Smit JH, McCarthy MI, van Duijn CM, Peltonen L; for the ENGAGE Consortium. Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. Nat Genet. 2008; 41: 47 - 55.
  • Knežević A, Polašek O, Gornik O, Rudan I, Campbell H, Hayward C, Wright A, Kolčić I, O'Donoghue N, Bones J, Rudd P, Lauc G. Variability, Heritability and Environmental Determinants of the Human Plasma N-Glycome. J Proteome Res 2008: 8: 694 - 701.
  • Kolz M, Johnson T, Sanna S, Teumer A, Vitart V, Perola M, Mangino M, Albrecht E, Wallace C, Farrall M, Johansson A, Nyholt DR, Aulchenko Y, Beckmann JS, Bergmann S, Bochud M, Brown M, Campbell H; EUROSPAN Consortium, Connell J, Dominiczak A, Homuth G, Lamina C, McCarthy MI; ENGAGE Consortium, Meitinger T, Mooser V, Munroe P, Nauck M, Peden J, Prokisch H, Salo P, Salomaa V, Samani NJ, Schlessinger D, Uda M, Völker U, Waeber G, Waterworth D, Wang-Sattler R, Wright AF, Adamski J, Whitfield JB, Gyllensten U, Wilson JF, Rudan I, Pramstaller P, Watkins H; PROCARDIS Consortium, Doering A, Wichmann HE; KORA Study, Spector TD, Peltonen L, Völzke H, Nagaraja R, Vollenweider P, Caulfield M; WTCCC, Illig T, Gieger C. Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations. PLoS Genet. 2009 Jun;5(6):e1000504.
  • Barbalić M, Narančić NS, Skarić-Jurić T, Peričić Salihović M, Klarić IM, Lauc LB, Janićijević B, Farrall M, Rudan I, Campbell H, Wright AF, Hastie ND, Rudan P. A Quantitative Trait Locus for SBP Maps Near KCNB1 and PTGIS in a Population Isolate. Am J Hypertens. 2009: 22: 663-8.
  • Tenesa A, Campbell H, Theodoratou E, Dunlop L, Cetnarskyj R, Farrington SM, Dunlop MG. Common genetic variants at the MC4R locus are associated with obesity, but not with dietary energy intake or colorectal cancer in the Scottish population. Int J Obes (Lond) 2009; 33(2): 284-8.
  • McQuillan R, Leutenegger AL, Abdel-Rahman R, Pericic M, Barac-Lauc L, Smolej-Narancic N, Janicijevic B, Franklin CS, Polasek O, Tenesa A, Farrington SM, MacLeod AK, Rudan P, Hayward C, Vitart V, Rudan I, Wild SH, Dunlop MG, Wright AF, Campbell H, Wilson JF. Runs of homozygosity in European populations. Amer J Hum Genet 2008: 83: 359 - 72.
  • COGENT Study, Houlston RS, Webb E, Broderick P, Pittman AM, Di Bernardo MC, Lubbe S, Chandler I, Vijayakrishnan J, Sullivan K, Penegar S; Colorectal Cancer Association Study Consortium, Carvajal-Carmona L, Howarth K, Jaeger E, Spain SL, Walther A, Barclay E, Martin L, Gorman M, Domingo E, Teixeira AS; CoRGI Consortium, Kerr D, Cazier JB, Niittymäki I, Tuupanen S, Karhu A, Aaltonen LA, Tomlinson IP, Farrington SM, Tenesa A, Prendergast JG, Barnetson RA, Cetnarskyj R, Porteous ME, Pharoah PD, Koessler T, Hampe J, Buch S, Schafmayer C, Tepel J, Schreiber S, Völzke H, Chang-Claude J, Hoffmeister M, Brenner H, Zanke BW, Montpetit A, Hudson TJ, Gallinger S; International Colorectal Cancer Genetic Association Consortium, Campbell H, Dunlop MG. Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer. Nat Genet. 2008; 40: 1426 - 35.
  • Lees CW, Zacharias W, Tremelling M, Noble CL, Nimmo ER, Tenesa A, Cornelius J, Gwo-Tzer Ho, Tokvist L, Linfors U, Lofberg R, Farrington S, Fitch P, Drummond HE, Arnott IDR, Appelman HD, Loane J, Diehl L, Campbell H, Dunlop MG, Parkes M, Howie SEM, Gumucio DL, Satsangi J. GLI-1 is an IBD2 susceptibility locus for ulcerative colitis: evidence for a role of hedgehog signalling in regulating colonic inflammatory pathways. PLoS Med 2008: 5: e239
  • Johansson Å, Marroni F, Hayward C, Franklin CS, Kirichenko AV, Jonasson I, Hicks AA, Vitart V, Isaacs A, Axenovich T, Campbell S, Dunlop MG, Floyd J, Hastie N, Knott S, Kolcic I, Pichler I, Polasek O, Tenesa A, Wild SH, Zorkoltseva IV, Meitinger T, Wilson JF, Rudan I, Campbell H, Pattaro C, Pramstaller P, Oostra BA, Wright AF, van Duijn CM, Aulchenko YS, Gyllensten U on behalf of the EUROSPAN Consortium Common variants of the JAZF1 gene associated with height identified by linkage and whole genome association analysis. Human Mol Genet 2008: 18: 373 -80.
  • Theodoratou E, Farrington SM, Tenesa A, McNeill G, Cetnarskyj R, Barnetson RA, Porteous ME, Dunlop MG, Campbell H. Dietary vitamin B6 intake and the risk of colorectal cancer. Cancer Epidemiol Biomarkers Prev 2008;17(1):171-82.
  • Theodoratou E, Campbell H, Tenesa A, McNeill G, Cetnarskyj R, Barnetson RA, Porteous ME, Dunlop MG, Farrington SM. Modification of the associations between lifestyle, dietary factors and colorectal cancer risk by APC variants. Carcinogenesis 2008; 29(9):1774-80
  • Theodoratou E, Farrington SM, Tenesa A, McNeill G, Cetnarskyj R, Barnetson RA, Porteous ME, Dunlop MG, Campbell H. Modification of the inverse association between dietary vitamin D intake and colorectal cancer risk by a FokI variant supports a chemoprotective action of Vitamin D intake mediated through VDR binding. Int J Cancer 2008;123(9):2170-9
  • Campbell H, Duke T, English M, Carai S, Tamburlini G, Weber M. Global initiatives for improving hospital care for children: state of the art and future prospects Paediatrics 2008: 121: e984-92.
  • Rudan I, Boschi-Pinto C, Biloglav Z, Mulholland K, Campbell H. The Epidemiology and Etiology of Childhood Pneumonia Bull WHO 2008: 86: 408-16.
  • Rudan I, Campbell H. A new role for health workers in preventing deaths from childhood pneumonia. Lancet 2008: in press
  • Duke T, Campbell H, Graham S. Ambulatory oral amoxicillin for severe pneumonia in children. Lancet. 2008; 371 :1333
  • Jaeger E, Webb E, Howarth K, Carvajal-Carmona L, Rowan A, Broderick P, Walther A, Spain S, Pittman A, Kemp Z, Sullivan K, Heinimann K, Lubbe S, Domingo E, Barclay E, Martin L, Gorman M, Chandler I, Vijayakrishnan J, Wood W, Papaemmanuil E, Penegar S, Qureshi M; members of the CORGI Consortium, Farrington S, Tenesa A, Cazier JB, Kerr D, Gray R, Peto J, Dunlop M, Campbell H, Thomas H, Houlston R, Tomlinson I. Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk. Nat Genet. 2008; 40: 26-8.
  • Vitart V, Rudan I, Hayward C, Floyd J, Gray, NK, Palmer CNA, Knott SA, Kolcic I, Polasek O, Graessler J, Wilson JF, Marinaki A, Riches PL, Janicijevic B, Smolej-Narancic N, Gorgoni B, Morgan J, Campbell S, Biloglav Z, Barac-Lauc L, Pericic M, Martinovic Klaric I, Zgaga L, Hohenstein P, Wild SH, Shu X, Kimber CH, Richardson WA, Tenesa A, Fairbanks LD, Aringer M, McKeigue PM, Ralston S, Morris AD, Rudan P, Hastie ND, Campbell H, Wright AF. SLC2A9 is a novel uric acid transporter influencing serum urate concentrations, urate excretion and gout. Nat Genet 2008: 40: 437 - 442.
  • Tomlinson I, Webb E, Carvajal-Carmona L, Broderick P, Howarth K, Pittman A, Spain S, Lubbe S, Walther A, Sullivan K, Jaeger E, Rowan A, Vijayakrishnan J, Domingo E, Chandler I, Kemp Z, Qureshi M, Farrington S, Tenesa A, Prendergast JGD, Barnetson RA, Penegar S, Barclay E, Wood W, Martin L, Gorman M, Thomas H, Peto J, Bishop T, Gray R, Maher E, Lucassen A, Kerr D, Evans G, Schafmayer C, Buch S, Volzke H, Hampe J, Schreiber S, John U, Koessler T, Pharoah PDP, van Wezel T, Morreau H, Wijnen J, Lipton L, Hopper JL, Southey M, Giles G, Severi G, Castellvi-Bel S, Ruiz-Ponte C, Carracedo A, Castells A, Forsti A, Hemminki K, Vodicka P, Naccarati A, Lipton L, Ho J, Cheng K, Sham P, Luk J, Agundez J, Ladero J, de la Hoya M, Caldes T, Niittymaki I, Tuupanene S, Karhu A, Aaltonen L, Cazier J, Campbell Hǂ, Dunlop MGǂ, Houlston RSǂ [ǂ joint senior authors] A genome-wide association study identifies novel colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3. Nat Genet 2008; 40: 623-30.
  • Tenesa A, Farrington SM, Prendergast JDG, Porteous ME, Walker M, Haq N, Barnetson RA, Theodoratou E, Cetnarskyj R, Cartwright N, Semple C, Clark AJ, Reid FJL, Smith LA, Kavoussanakis K, Koessler T, Pharoah PDP, Buch S, Schafmayer C, Tepel J, Schreiber S, Völzke H, Schmidt CO, Hampe J, Wilkening S, Canzian F, Chang-Claude J, Hoffmeister M, Brenner H, Capella G, Moreno V, Deary IJ, Starr JM, Tomlinson IM, Kemp Z, Carvajal-Carmona L, Webb E, Broderick P, Vijayakrishnan J, Houlston RS, Rennert G, Ballinger D, Rozek L, Gruber SB, Matsuda K, Kidokoro T, Nakamura Y, Zanke BW, Greenwood CMT, Rangrej J, Kustra R, Montpetit A, Hudson TJ, Gallinger S, Campbell H, Dunlop MG. A genome-wide association scan identifies a new colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21. Nat Genet 2008; 40: 631-7.
  • Campbell H, Wood R. Preventive pediatrics. In: McIntosh N, Helms P, Smyth R, Logan S, eds. Forfar & Arneil's Textbook of Pediatrics. 7th ed. Edinburgh; Elsevier, 2008, pp27-44.
  • Theodoratou E, Kyle J, Cetnarskyj R, Farrington SM, Tenesa A, Barnetson R, Porteous M, Dunlop M, Campbell H. Dietary flavonoids and the risk of colorectal cancer. Cancer Epidemiol Biomarkers Prev 2007; 16(4):684-93
  • Theodoratou E, McNeill G, Cetnarskyj R, Farrington SM, Tenesa A, Barnetson R, Porteous M, Dunlop M, Campbell H. Dietary fatty acids and colorectal cancer: a case-control study. Am J Epidemiol 2007;166(2):181-95
  • Povey JE, Darakhshan F, Robertson K, Bisset Y, Mekky M, Rees J, Doherty V, Kavanagh G, Anderson N, Campbell H, MacKie RM, Melton DW (2007) DNA repair gene polymorphisms and genetic predisposition to cutaneous melanoma. Carcinogenesis 28:1087-1093
  • Zanke BW, Greenwood CMT, Rangrej J, Kustra R, Tenesa A, Farrington SM, Prendergast J, Olschwang S, Chiang T, Crowdy E, Ferretti V, Laflamme P, Sundararajan S, Roumy S, Olivier JF, Robidoux F, Sladek R, Montpetit A, Campbell P, Bezieau S, O'Shea AM, Zogopoulos G, Cotterchio M, Newcomb P, McLaughlin J, Younghusband B, Green R, Green J, Porteous MEM, Campbell H, Blanche H, Sahbatou M, Tubacher E, Bonaiti C, Buecher B, Kury S, Chanock SJ, Potter J, Thomas G, Gallinger S, Hudson TJ, Dunlop MG. A Colorectal Cancer Susceptibility Loci on Chromosome 8 Identified by a Genome-Wide Association Scan. Nat Genet 2007; 39: 989 - 994
  • Rudan I, El Arifeen S, Black RE, Campbell H. Childhood pneumonia and diarrhoea: setting our priorities right. Lancet Infect Dis. 2007; 7: 56-61
  • Campbell H, Carothers AD, Rudan I, Hayward C, Biloglav Z, Barac L, Pericic M, Janicijevic B, Smolej-Narancic N, Polasek O, Kolcic I, Weber JL, Hastie ND, Rudan P, Wright AF. Effects of genome-wide heterozygosity on a range of biomedically relevant human quantitative traits. Hum Mol Genet 2007: 16: 233 - 41
  • Lim Y-W, Steinhoff M, Girosi F, Holtzman D, Campbell H, Boer R, Black RE, Mulholland K. Reducing the Global Burden of Acute Lower Respiratory Infections in Children: The Potential Contribution of New Diagnostics. Nature 2006; S1: 9-18
  • Farrington SM, Tenesa A, Barnetson R, Wiltshire A, Prendergast J, Porteous M, Campbell H, Dunlop MG. Colorectal cancer risk in monoallelic carriers of MYH variants. Amer J Hum Genet 2006; 79: 771-2
  • Smith BH, Campbell H, Blackwood D, Connell J, Connor M, Deary IJ, Dominiczak AF, Fitzpatrick B, Ford I, Jackson C, Haddow G, Kerr S, Lindsay R, McGilchrist M, Morton R, Murray G, Palmer CN, Pell JP, Ralston SH, St Clair D, Sullivan F, Watt G, Wolf R, Wright A, Porteous D, Morris AD. Generation Scotland: the Scottish Family Health Study; a new resource for researching genes and heritability. BMC Med Genet. 2006; 7:74
  • Rudan I, Campbell H, Carothers AD, Hastie ND, Wright AF. Contribution of consanguinuity to polygenic and multifactorial diseases. Nat Genet. 2006;38: 1224-5.
  • Tenesa A, Campbell H, Barnetson R, Porteous M, Dunlop M, Farrington SM. Association of MUTYH and colorectal cancer. Brit J Cancer 2006: 95: 239-42
  • Duke T, Kelly J, Weber M, English M, Campbell H. Hospital care for children in developing countries: clinical guidelines and need for evidence (editorial). J Trop Paeds 2006; 52: 1-2
  • Vitart V, Biloglav Z, Hayward C, Janicijevic B, Smolej-Narancic N, Barac L, Pericic M, Klaric IM, Skaric-Juric T, Barbalic M, Polasek O, Kolcic I, Carothers A, Rudan P, Hastie N, Wright A, Campbell H, Rudan I. 3000 years of solitude: extreme differentiation in the island isolates of Dalmatia, Croatia. Eur J Hum Genet, 14:478-87, 2006.
  • Carothers AD, Rudan I, Kolcic I, Polasek O, Hayward C, Wright AF, Campbell H, Teague P, Hastie ND, Weber JL. Estimating human inbreeding coefficients: comparison of genealogical and marker heterozygosity approaches. Ann Hum Genet 2006: 70:666-676, .
  • Kyaw M, Holmes EM, Toolis F, Wayne B, Chalmers J, Jones IG, Campbell H. Evaluation of severe infection and survival after splenectomy in Scotland 1988 - 98. Amer J Med: 2006: 119: 276 e1-7
  • Barnetson R, Tenesa A, Farrington SM, Nicholl ID, Porteous ME, Campbell H, Dunlop MG. Identification and Survival of Carriers of Mutations in DNA Mismatch Repair Genes in Colon Cancer. New Engl J Med 2006; 354: 2751 - 2763.
  • Satsangi J, Campbell H, Dunlop M, Porteous M. Molecular genetics in gastroenterology: from research success to clinical application? Nature Clinical Practice (Gastroenterology and Hepatology) 2005: 2: 118-9
  • Bryce J, Boschi-Pinto C, Shibuya K, Black RE, Campbell H, Rudan I, Lanata C, Mendoza W, Rowe AK, Steketee RW, Schellenberg JA, Carneiro I, Roca-Feltrer A, Lawn J, Bhutta Z, Morris S, Fenn B, Cousens S, Mulholland K: WHO estimates of the causes of death in children. Lancet 2005: 365: 1147-1152.
  • Mitchell RJ, Brewster D, Campbell H, Porteous MEM, Dunlop MG. Prevalence of Family History of Colorectal Cancer in the General Population. Brit J Surg 2005: 92: 1161 - 4
  • Price J, Campbell C, Sells J, Weller D, Campbell H. Impact of UK Colorectal Screening Pilot on Hospital Services. Public Health 2005: 27: 246 - 53
  • Bryce J, Boschi-Pinto C, Shibuya K, Black RE and the WHO Child Health Epidemiology Reference Group (including Campbell H). New WHO estimates of the causes of child deaths. Lancet 2005: 365: 1147 - 52
  • Rudan I, Lawn J, Cousens S, Rowe AK, Mendoza W, Lanata CF, Boschi-Pinto C, Tomaskovic L, Roca-Feltrer A, Carneiro I, Schellenberg JA, Polasek O, Weber M, Bryce, Morris SS, Black RE, Campbell H. Gaps in Policy-Relevant Child Health Information: do poor children count? Lancet 2005: 365: 2031-40.
  • Holloway S, Porteous M, Cetnarskyj R, Rush R, Appleton S, Gorman D, Campbell H. Referrals of patients to colorectal cancer genetics services in South-East Scotland. Familial Cancer 2005; 4: 151-61
  • Farrington SM, Tenesa A, Barnetson R, Wiltshire A, Prendergast J, Porteous M, Campbell H, Dunlop MG. Germline susceptibility to early onset colorectal cancer due to recessive inheritance of base excision repair gene defects. Amer J Hum Genet 2005;77: 112-9
  • Vitart V, Carothers AD, Suffolk R, Hayward C, Teague P, Hastie ND, Campbell H, Wright AF. Increased Level of Linkage Disequilibrium in Rural Compared to Urban Communities: A Factor to Consider in Association Study Design Am J Hum Genet 2005;76: 763 - 72.
  • UK Colorectal Cancer Screening Pilot (including Campbell H). Results of the first round of a demonstration pilot of screening for colorectal cancer in the UK. BMJ 2004; 329: 133 - 5
  • Wallace E, Hinds A, Campbell H, Horobin J, Cetnarskyj R, Porteous M. A cross-sectional survey to estimate the prevalence of family history of colorectal, breast and ovarian cancer in a general practice population. Brit J Cancer: 2004: 91: 1575 - 9
  • Lanata F, Rudan I, Boschi-Pinto C, Tomašković L, Cherian T, Weber M, Campbell H: Methodological and quality issues in epidemiological studies of acute lower respiratory infections in children in developing countries. Int J Epidemiol, 33: 1362-1372, 2004.
  • Holloway S, Porteous M, Cetnarskyj R, Anderson E, Rush R, Fry A, Gorman D, Steel M, Campbell H. Patient satisfaction with and relative costs of two different models of cancer genetics services in south east Scotland. Brit J Cancer: 2004; 90: 582-9.
  • Rudan I, Tomaskovic L, Boschi-Pinto C, Campbell H. Estimate of global incidence of clinical pneumonia in children under five years. Bull WHO 2004: 82: 895 - 903
  • Mitchell RJ, Brewster D, Campbell H, Porteous MEM, Bird CC, Wyllie AH, Dunlop MG. Accuracy of reporting of family history of cancer. Gut 2004: 53: 291 - 5.
  • Duke T, Tamburlini G, Paediatric Quality Care Group (including Campbell H). Improving the quality of paediatric care in peripheral hospitals in developing countries. Arch Dis Child 2003; 88: 563-5.
  • Kyaw MH, Christie P, Clarke SC, Mooney J, Ahmed S, Jones IG, Campbell H. Invasive pneumococcal disease in Scotland in 1999-2001: use of record linkage to explore associations between patients and disease in relation to future vaccination policy. Clin Infect Dis. 2003: 37: 1283 - 91
  • Campbell H, Holloway S, Cetnarskyj R, Anderson E, Rush R, Fry A, Gorman D, Steel M, Porteous M. Referrals of women with a family history of breast cancer from primary care to cancer genetics services in SE Scotland. Brit J Cancer 2003: 89: 1650 - 1656
  • Porteous M, Dunkley M Appleton S, Catt S, Dunlop MG, Campbell H, Cull A. Is it acceptable to approach colorectal cancer patients at diagnosis to discuss genetic testing? A pilot study. Brit J Cancer 2003: 89: 1400-2.
  • Fry A, Cull A, Appleton S, Rush R, Holloway S, Gorman D, Cetnarskyj R, Thomas R, Campbell J, Anderson E, Steel CMS, Porteous M, Campbell H. A Randomised Controlled Trial of Breast Cancer Genetics Services in South East Scotland: Psychological Impact: Psychological Impact of Breast Cancer Genetics Services. Brit J Cancer 2003: 89: 653 - 659.
  • Wright A, Charlesworth B, Rudan I, Carothers A, Campbell H. A polygenic basis for late-onset disease. Trends in Genetics 2003; 19: 97 - 106
  • Rudan I, Rudan D, Campbell H, Carothers A, Wright A, Deka R, Smolej-Narancic N, Janicijevic B, Rudan P. Inbreeding and risk of complex chronic diseases J Med Genet 2003;40: 925-932
  • Rudan I, Campbell H, Carothers A, Wright A, Smolej-Narancic N, Skaric-Juric T, Rudan P. Inbreeding and the genetic complexity of human essential hypertension Genetics 2003;163: 1011 - 21

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